Fiesty Pete Rose and triple crown winner Carl Yastrzemski are the career leaders for most games played. Rose played in 3562 games and Yaz in 3308. Third on the list is Hank Aaron (3298), followed by Rickey Henderson (3081) and Ty Cobb (3034). Among the active players, Omar Visquel and Derek Jeter are 1-2. Visquel has played in 2968 games and Jeter in 2585.